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| Original Article | |||||
| Dementia and Neurocognitive Disorders 2022: 21: 1: 17-29 | |||||
| A Comparison Between the Performances of Verbal and Nonverbal Fluency Tests in Discriminating Between Mild Cognitive Impairments and Alzheimer’s Disease Patients and Their Brain Morphological Correlates | |||||
|---|---|---|---|---|---|
| Seyul Kwak , 1 Seong A Shin , 2,3 Hyunwoong Ko,4 Hairin Kim , 4 Dae Jong Oh,4 Jung Hae Youn,5 Jun-Young Lee , 1 Yu Kyeong Kim 3 | |||||
| 1 Department of Psychology, Pusan National University, Busan, Korea 2 Department of Biomedical Sciences, Seoul National University, Seoul, Korea 3 Department of Nuclear Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea 4 Department of Psychiatry, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea 5 Department of Art Therapy & Counseling Psychology, CHA University, Pocheon, Korea | |||||
| A Comparison Between the Performances of Verbal and Nonverbal Fluency Tests in Discriminating Between Mild Cognitive Impairments and Alzheimer’s Disease Patients and Their Brain Morphological Correlates | |||||
| Seyul Kwak , 1 Seong A Shin , 2,3 Hyunwoong Ko,4 Hairin Kim , 4 Dae Jong Oh,4 Jung Hae Youn,5 Jun-Young Lee , 1 Yu Kyeong Kim 3 | |||||
| 1 Department of Psychology, Pusan National University, Busan, Korea 2 Department of Biomedical Sciences, Seoul National University, Seoul, Korea 3 Department of Nuclear Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea 4 Department of Psychiatry, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea 5 Department of Art Therapy & Counseling Psychology, CHA University, Pocheon, Korea | |||||
| Background and Purpose: Verbal and nonverbal fluency tests are the conventional methods for examining executive function in the elderly population. However, differences in impairments result in fluency tests in patients with mild cognitive impairments (MCIs) and Alzheimer’s disease (AD) and in neural correlates underlying the tests still necessitate concrete evidence. Methods: We compared the test performances in 27 normal controls, 28 patients with MCI, and 20 with AD, and investigated morphological changes in association with the test performances using structural magnetic imaging. Results: Patients with AD performed poorly across all the fluency tests, and a receiver operating characteristics curve analysis revealed that only category fluency test discriminated all the 3 groups. Association, category, and design fluency tests involved temporal and frontal regions, while letter fluency involved the cerebellum and caudate. Conclusions: Category fluency is a reliable measure for screening patients with AD and MCI, and this efficacy might be related to morphological correlates that underlie semantic and executive processing. |
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| Key Words: Mild Cognitive Impairment; Alzheimer’s Disease; Gray Matter; Language; Executive Function; Neuropsychological Tests | |||||
| 대한치매학회지 (Dementia and Neurocognitive Disorders) | |||||
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