LETTER TO THE EDITOR |
Dementia and Neurocognitive Disorders 2021: 20: 4: 1-4 |
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Neurosyphilis as a Rare Cause of Mild Cognitive Impairment and Depression: Two Case Reports and Literature Review |
Kyung Won Lee, Yun Jeong Hong , Si Baek Lee, Seong Hoon Kim, Yun Sang Oh, Yongbang Kim, Jeong Wook Park |
Department of Neurology, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, Uijeongbu, Korea |
Neurosyphilis as a Rare Cause of Mild Cognitive Impairment and Depression: Two Case Reports and Literature Review |
Kyung Won Lee, Yun Jeong Hong , Si Baek Lee, Seong Hoon Kim, Yun Sang Oh, Yongbang Kim, Jeong Wook Park |
Department of Neurology, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, Uijeongbu, Korea |
Syphilis infection caused by Treponema pallidum is also referred to as the ‘great imposter' due to its varied manifestations. Neurosyphilis is tertiary syphilis that involves the brain. ‘General paresis’ is a later manifestation of neurosyphilis.1-3 With the widespread clinical use of penicillin, neurosyphilis has become rare and is not typically considered by clinicians. However, because neurosyphilis can be a cause of treatable dementia, there is a need to consider neurosyphilis as a possible cause of mild cognitive impairment (MCI). We present two cases that initially presented with cognitive decline, depression, and gait instability and were later diagnosed with general paresis.
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