학회지

권호별 검색

  • HOME
  • 학회지
  • 학회지
  • 권호별 검색
Original Article
Dementia and Neurocognitive Disorders 2020: 19: 1: 1-9

전문보기

Determining the Neurocognitive Status and the Functional Ability of Patients to Screen for HIV-Associated Neurocognitive Disorder (HAND)
Ritika Agarwal , Ravinder Singh Aujla , Amit Gupta , Mukesh Kumar
Department of Medicine, Chandra Laxmi Hospital, Vaishali Ghaziabad, UP, India
Determining the Neurocognitive Status and the Functional Ability of Patients to Screen for HIV-Associated Neurocognitive Disorder (HAND)
Ritika Agarwal , Ravinder Singh Aujla , Amit Gupta , Mukesh Kumar
Department of Medicine, Chandra Laxmi Hospital, Vaishali Ghaziabad, UP, India
Background and Purpose: To adequately evaluate the extent of neurocognitive impairment in
patient living with human immunodeficiency virus (PLHIV), a battery of neuropsychological
tests is typically administered which are neither cost effective nor time efficient in the
outpatient clinical setting. The aim of the study was to assess neurocognitive status and
functional ability of people living with HIV and find a brief screening tool to identify those
who would benefit from a full diagnostic evaluation.
Methods: The study enrolled 160 PLHIV (80 pre-antiretroviral therapy [ART] and 80 on ART)
fulfilling the inclusion and exclusion criteria. Neurocognitive assessment and an assessment
of Functional ability was done by using the Montreal Cognitive Assessment (MoCA) and
Lawton and Brody Instrumental Activities of Daily Living Scale scale, respectively.
Results: The study population consisted of 75.6% males and 24.4% females with mean age of
44±10 years. The overall prevalence of HIV associated neurocognitive disorder (HAND) in the
study subjects was 52.5%. Of these, 47.5% had asymptomatic neurocognitive impairment and
5% had minor neurocognitive disorder. In MoCA, the most frequently affected domains were
Language (97.6%), visuospatial ability (92.9%) and memory (71.4%).
Conclusions: The prevalence of HAND in both groups were similar suggesting that
neurocognitive impairment starts early in HIV infection. Memory and Visuospatial function
impairment had the most predictive potential for detecting the presence of HAND. HAND
screening is recommended in all PLHIV at enrolment into care. Simple tools like MoCA can
be used in busy outpatient settings by healthcare workers to screen for HAND.
Key Words: HIV; Neurocognitive Disorder; Neurocognitive Assessment; Dementia: HAND
대한치매학회지 (Dementia and Neurocognitive Disorders)