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| Original Article | |||||
| Dementia and Neurocognitive Disorders 2018: 17: 2: 41-49 | |||||
| Plasma Oligomeric Beta Amyloid in Alzheimer's Disease with History of Agent Orange Exposure | |||||
|---|---|---|---|---|---|
| YoungSoon Yang ,1 Vo Van Giau,2 Seong Soo A. An,2 SangYun Kim 3 | |||||
| 1Department of Neurology, Veterans Health Service Medical Center, Seoul, Korea 2Department of Bionano Technology, Gachon University, Seongnam, Korea 3Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Seongnam, Korea | |||||
| Plasma Oligomeric Beta Amyloid in Alzheimer's Disease with History of Agent Orange Exposure | |||||
| YoungSoon Yang ,1 Vo Van Giau,2 Seong Soo A. An,2 SangYun Kim 3 | |||||
| 1Department of Neurology, Veterans Health Service Medical Center, Seoul, Korea 2Department of Bionano Technology, Gachon University, Seongnam, Korea 3Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Seongnam, Korea | |||||
| Background and Purpose: During the Vietnam War, many Korean soldiers were exposed to Agent Orange. Until now, there existed only limited evidence of association between exposure to Agent Orange and Alzheimer's disease (AD). The main pathological feature of AD is brain amyloidosis. To explore the pathophysiological characteristic of AD with Agent Orange exposure, we compared newly developed amyloid beta (Aβ) oligomer levels in plasma between AD with Agent Orange exposure and without exposure. Methods: We recruited 48 AD patients with Agent Orange exposure and 66 AD patients without Agent Orange. Using the Multimer Detection System technique, which was based on an enzyme-linked immunosorbent assay, we measured Aβ oligomers in the plasma of study subjects. Results: Compared to normal control patients, plasma Aβ oligomer levels were higher in AD patients regardless of history of Agent Orange exposure. However, AD patients with Agent Orange exposure showed higher plasma Aβ oligomer levels than AD patients without Agent Orange. Discussion: This study showed higher plasma Aβ oligomer levels in AD patients with Agent Orange exposure compared to AD patients without Agent Orange. This finding suggests the possibility of a different pathophysiology of AD patients with Agent Orange exposure from AD patients without Agent Orange. |
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| Key Words: Agent Orange; Alzheimer's Disease; Plasma Aβ Oligomer | |||||
| 대한치매학회지 (Dementia and Neurocognitive Disorders) | |||||
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