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Case Report
Dementia and Neurocognitive Disorders 2018: 17: 1: 37-40

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Emerging of Explosive Speech after Olanzapine in Multiple System Atrophy Patient
Yong Sung Kim , Seung Jae Kim , Jongmin Lee , Hee-Jin Kim
Department of Neurology, College of Medicine, Hanyang University, Seoul, Korea
Emerging of Explosive Speech after Olanzapine in Multiple System Atrophy Patient
Yong Sung Kim , Seung Jae Kim , Jongmin Lee , Hee-Jin Kim
Department of Neurology, College of Medicine, Hanyang University, Seoul, Korea
Background: Cerebellum has an important role in sensorimotor control including speech.
Multiple system atrophy (MSA) is a sporadic and rapidly progressive neurodegenerative
disorder that presents with autonomic failure in combination with Parkinsonism or
cerebellar ataxia.
Case Report: We report a case of MSA-cerebellum subtype associated with emergence of
irreversible explosive speech following olanzapine therapy.
Conclusions: Further investigation into speech problems in MSA according to subtype and
disease severity is needed, and side effects of olanzapine therapy should also be considered.
Key Words: Antipsychotic Agents; Multiple System Atrophy; Speech
대한치매학회지 (Dementia and Neurocognitive Disorders)