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| Original Article | |||||
| Dementia and Neurocognitive Disorders 2017: 16: 3: 78-82 | |||||
| Hypertension and Neuropsychiatric Symptoms in Patients with Drug-Naïve Alzheimer’s Disease | |||||
|---|---|---|---|---|---|
| Inha Hwang,1* Kyoung-Hwa Baek,2* Jeong Ho Han,1 Sang-Won Ha,1 YoungSoon Yang1 | |||||
| 1Department of Neurology, Veterans Health Service Medical Center, Seoul, Korea 2Department of Nursing, Gyeongbuk College of Health, Gimcheon, Korea | |||||
| Hypertension and Neuropsychiatric Symptoms in Patients with Drug-Naïve Alzheimer’s Disease | |||||
| Inha Hwang,1* Kyoung-Hwa Baek,2* Jeong Ho Han,1 Sang-Won Ha,1 YoungSoon Yang1 | |||||
| 1Department of Neurology, Veterans Health Service Medical Center, Seoul, Korea 2Department of Nursing, Gyeongbuk College of Health, Gimcheon, Korea | |||||
| Background and Purpose: Neuropsychiatric symptoms (NPS) such as anxiety, depression, and delusions affect up to 90% of all patients with Alzheimer’s disease (AD). NPS is associated with significant caregiver burden and patient distress. Given the severe burden of NPS in AD, it is critical to know potential modifiable risk factors of NPS in AD. This study explores the association between hypertension and NPS in patients with drug-naïve AD. Methods: We reviewed medical records of 149 patients with AD with (n=80) and without (n=69) hypertension. NPS were assessed using the Korean version of Neuropsychiatric Inventory (KNPI) Affective psychotic and behavior symptom clusters were assessed separately. Results: The total score of K-NPI was not significantly different between patients with AD with and without hypertension. Among K-NPI domains, scores of depression/dysphoria (p=0.045), anxiety (p=0.022), and apathy/indifference (p=0.037) were significantly higher in patients with AD with hypertension. Systolic blood pressure (BP) was associated with higher total K-NPI and affective symptom cluster scores. Diastolic BP was associated with affective symptom cluster scores. Conclusions: Results suggest that hypertension increases risk of specific NPS in patients with AD. Among NPS, hypertension was associated with affective symptom cluster. |
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| Key Words: hypertension Alzheimers disease neuropsychiatric symptoms | |||||
| 대한치매학회지 (Dementia and Neurocognitive Disorders) | |||||
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