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| Case Report | |||||
| Dementia and Neurocognitive Disorders 2016: 15: 4: 170-173 | |||||
| Neurosyphilis Mimicking Creutzfeldt-Jakob Disease | |||||
|---|---|---|---|---|---|
| Jae-Won Jang,1 Jeong Hoon Park,1 Yong Jun Eo,1 Seong Heon Kim,1 Kyung Ho Choi,2 SangHak Yi,2 Young Ho Park,2 SangYun Kim2 | |||||
| 1Department of Neurology, Kangwon National University Hospital, Chuncheon, Korea 2Department of Neurology, Seoul National University College of Medicine, Clinical Neuroscience Center, Seoul National University Bundang Hospital, Seongnam, Korea | |||||
| Neurosyphilis Mimicking Creutzfeldt-Jakob Disease | |||||
| Jae-Won Jang,1 Jeong Hoon Park,1 Yong Jun Eo,1 Seong Heon Kim,1 Kyung Ho Choi,2 SangHak Yi,2 Young Ho Park,2 SangYun Kim2 | |||||
| 1Department of Neurology, Kangwon National University Hospital, Chuncheon, Korea 2Department of Neurology, Seoul National University College of Medicine, Clinical Neuroscience Center, Seoul National University Bundang Hospital, Seongnam, Korea | |||||
| Background As rapidly progressive dementia (RPD), general paresis and Creutzfeldt-Jakob disease (CJD) may have overlapping clinical presentation due to a wide variety of clinical manifestations. Case Report A 57-year-old man presented with rapid progressive cognitive decline, behavioral change, ataxic gait, tremor and pyramidal signs for 3 months. In addition to these multiple systemic involvements, positive result for the cerebrospinal fluid (CSF) 14-3-3 protein tentatively diagnosed him as probable CJD. However, due to increased serum rapid plasma reagin, venereal disease research laboratory, and fluorescent treponemal antibody-absorption reactivity in CSF, the final diagnosis was changed to general paresis. Conclusions A patient with RPD needs to be carefully considered for differential diagnosis, among a long list of diseases. It is important to rule out CJD, which is the most frequent in RPD and is a fatal disease with no cure. Diagnostic criteria or marker of CJD, such as 14-3-3 protein, may be inconclusive, and a typical pattern in diffusion-weighted imaging is important to rule out other reversible diseases. |
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| Key Words: neurosyphilis, general paresis, rapidly progressive dementia, Creutzfeldt-Jakob disease. | |||||
| 대한치매학회지 (Dementia and Neurocognitive Disorders) |
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