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| Original Article | |||||
| Dementia and Neurocognitive Disorders 2016: 15: 3: 68-74 | |||||
| Clinical Predictors for Mild Cognitive Impairment Progression in a Korean Cohort | |||||
|---|---|---|---|---|---|
| Yong S. Shim,1 Dong Won Yang,1 Bora Yoon,2 Yunhwan Lee,3 Chang Hyung Hong,4 Sang Won Seo,5 Soo Jin Yoon,6 Jee Hyang Jeong,7 Moon Ho Park,8 Seong Hye Choi,9 Seong Yoon Kim10 | |||||
| 1Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea 2Department of Neurology, Konyang University College of Medicine, Daejeon, Korea Departments of 3Preventive Medicine and Public Health and 4Psychiatry, Ajou University School of Medicine, Suwon, Korea 5Department of Neurology, Sungkyunkwan University School of Medicine, Seoul, Korea 6Department of Neurology, Eulji University College of Medicine, Daejeon, Korea 7Department of Neurology, Ewha Womans University School of Medicine, Seoul, Korea 8Department of Neurology, Korea University College of Medicine, Seoul, Korea 9Department of Neurology, Inha University School of Medicine, Incheon, Korea 10Department of Psychiatry, University of Ulsan, College of Medicine, Seoul, Korea | |||||
| Clinical Predictors for Mild Cognitive Impairment Progression in a Korean Cohort | |||||
| Yong S. Shim,1 Dong Won Yang,1 Bora Yoon,2 Yunhwan Lee,3 Chang Hyung Hong,4 Sang Won Seo,5 Soo Jin Yoon,6 Jee Hyang Jeong,7 Moon Ho Park,8 Seong Hye Choi,9 Seong Yoon Kim10 | |||||
| 1Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea 2Department of Neurology, Konyang University College of Medicine, Daejeon, Korea Departments of 3Preventive Medicine and Public Health and 4Psychiatry, Ajou University School of Medicine, Suwon, Korea 5Department of Neurology, Sungkyunkwan University School of Medicine, Seoul, Korea 6Department of Neurology, Eulji University College of Medicine, Daejeon, Korea 7Department of Neurology, Ewha Womans University School of Medicine, Seoul, Korea 8Department of Neurology, Korea University College of Medicine, Seoul, Korea 9Department of Neurology, Inha University School of Medicine, Incheon, Korea 10Department of Psychiatry, University of Ulsan, College of Medicine, Seoul, Korea | |||||
| Background and Purpose Patients with mild cognitive impairment (MCI) and their caregivers are concerned with the likelihood and time course of progression to dementia. This study was performed to identify the clinical predictors of the MCI progression in a Korean registry, and investigated the effects of medications without evidence, frequently prescribed in clinical practice. Methods Using a Korean cohort that included older adults with MCI who completed at least one follow-up visit, clinical characteristics and total medical expenses including prescribed medications were compared between two groups: progressed to dementia or not. Cox proportional hazards regression analysis was conducted. Results During the mean 1.42±0.72 years, 215 (27.63%) of 778 participants progressed to dementia. The best predictors were age [hazard ratio (HR), 1.036; 95% confidence interval (CI), 1.006–1.067; p=0.018], apolipoprotein ε4 allele (HR, 2.247; 95% CI, 1.512–3.337; p<0.001), Clinical Dementia Rating scale-sum of boxes scores (HR, 1.367; 95% CI, 1.143–1.636; p=0.001), Instrumental Activities of Daily Living scores (HR, 1.035; 95% CI, 1.003–1.067; p=0.029), and lower Mini-Mental State Examination scores (HR, 0.892; 95% CI, 0.839–0.949; p<0.001). Total medical expenses were not different. Conclusions Our data are in accordance with previous reports about clinical predictors for the progression from MCI to dementia. Total medical expenses were not different between groups with and without progression. |
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| Key Words: cholinesterase inhibitors, dementia, mild cognitive impairment, predictors. | |||||
| 대한치매학회지 (Dementia and Neurocognitive Disorders) |
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