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Apolipoprotein E4: A Risk Factor for Successful Cognitive Aging
Review
Dementia and Neurocognitive Disorders 2016: 15: 3: 61-67	전문보기
Oh Dae Kwon
Department of Neurology, School of Medicine, Catholic University of Daegu, Daegu, Korea
Apolipoprotein E4: A Risk Factor for Successful Cognitive Aging
Oh Dae Kwon
Department of Neurology, School of Medicine, Catholic University of Daegu, Daegu, Korea
Apolipoprotein E is a plasma protein that has an important role in transport and metabolism of lipids in serum as well as central nervous system. Among the 3 common alleles, the ε2 allele has the most stable structure followed by ε3 and ε4 in order. There is evidence for a deleterious role of ε4 allele by atherosclerosis and amyloid beta accumulation in brain and body. The presence and gene dose of ε4 allele are risk factors for late-onset Alzheimer’s disease. Apolipoprotein E ε4 may have a role in the pathology of amyloid beta and tau and it has a strong relationship with the early onset of late-onset Alzheimer’s disease. However, early-onset Alzheimer’s disease has a weaker relationship with ε4 allele of apolipoprotein E.
Key Words: apolipoprotein E, polymorphism, Alzheimer’s disease.