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Factors Influencing Skin Tolerability to the Rivastigmine Patch in Patients with Alzheimer’s Disease
Original Article
Dementia and Neurocognitive Disorders 2015: 14: 1: 31-38	전문보기
Hae Ri Na,1 Moon Ho Park,2 SangYun Kim,3 Dong Won Yang,4 Seong-Hye Choi,5 Hyun Duk Yang,6 YoungSoon Yang,7 Hyun Jeong Han,8 Jung Seok Lee,9 Young-Chul Yoon,10 Seong-Ho Koh,11 Jung Eun Kim,12 Bon D. Ku,8 Hee-Jin Kim,13 Kyung Won Park,14 Eun-Joo Kim,15 Bora Yoon,16 Key Jung Park17
1Department of Neurology, Bobath Memorial Hospital, Seongnam, Korea 2Department of Neurology, Korea University College of Medicine, Korea University Ansan Hospital, Ansan, Korea 3Department of Neurology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea 4Department of Neurology, The Catholic University of Korea College of Medicine, Seoul St. Mary’s Hospital, Seoul, Korea 5Department of Neurology, Inha University College of Medicine, Inha University Hospital, Incheon, Korea 6Department of Neurology, Wonkwang University College of Medicine, Wonkwang University Sanbon Medical Center, Gunpo, Korea 7Department of Neurology, VHS Medical Center, Seoul, Korea 8Department of Neurology, Seonam University College of Medicine, Myongji Hospital, Goyang, Korea 9Department of Neurology, Jeju National University College of Medicine, Jeju National University Hospital, Jeju, Korea 10Department of Neurology, Chung-Ang University College of Medicine, Chung-Ang University Hospital, Seoul, Korea 11Department of Neurology, Hanyang University College of Medicine, Hanyang University Guri Hospital, Guri, Korea 12Department of Neurology, Ewha Womans University School of Medicine, Ewha Womans University Mokdong Hospital, Seoul, Korea 13Department of Neurology, Hanyang University College of Medicine, Hanyang University Seoul Hospital, Seoul, Korea 14Department of Neurology, Dong-A University College of Medicine, Dong-A University Medical Center, Busan, Korea 15Department of Neurology, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea 16Department of Neurology, Konyang University School of Medicine, Konyang University Hospital, Daejeon, Korea 17Department of Neurology, Kyung Hee University College of Medicine, Kyung Hee University Medical Center, Seoul, Korea
Factors Influencing Skin Tolerability to the Rivastigmine Patch in Patients with Alzheimer’s Disease
Hae Ri Na,1 Moon Ho Park,2 SangYun Kim,3 Dong Won Yang,4 Seong-Hye Choi,5 Hyun Duk Yang,6 YoungSoon Yang,7 Hyun Jeong Han,8 Jung Seok Lee,9 Young-Chul Yoon,10 Seong-Ho Koh,11 Jung Eun Kim,12 Bon D. Ku,8 Hee-Jin Kim,13 Kyung Won Park,14 Eun-Joo Kim,15 Bora Yoon,16 Key Jung Park17
1Department of Neurology, Bobath Memorial Hospital, Seongnam, Korea 2Department of Neurology, Korea University College of Medicine, Korea University Ansan Hospital, Ansan, Korea 3Department of Neurology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea 4Department of Neurology, The Catholic University of Korea College of Medicine, Seoul St. Mary’s Hospital, Seoul, Korea 5Department of Neurology, Inha University College of Medicine, Inha University Hospital, Incheon, Korea 6Department of Neurology, Wonkwang University College of Medicine, Wonkwang University Sanbon Medical Center, Gunpo, Korea 7Department of Neurology, VHS Medical Center, Seoul, Korea 8Department of Neurology, Seonam University College of Medicine, Myongji Hospital, Goyang, Korea 9Department of Neurology, Jeju National University College of Medicine, Jeju National University Hospital, Jeju, Korea 10Department of Neurology, Chung-Ang University College of Medicine, Chung-Ang University Hospital, Seoul, Korea 11Department of Neurology, Hanyang University College of Medicine, Hanyang University Guri Hospital, Guri, Korea 12Department of Neurology, Ewha Womans University School of Medicine, Ewha Womans University Mokdong Hospital, Seoul, Korea 13Department of Neurology, Hanyang University College of Medicine, Hanyang University Seoul Hospital, Seoul, Korea 14Department of Neurology, Dong-A University College of Medicine, Dong-A University Medical Center, Busan, Korea 15Department of Neurology, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea 16Department of Neurology, Konyang University School of Medicine, Konyang University Hospital, Daejeon, Korea 17Department of Neurology, Kyung Hee University College of Medicine, Kyung Hee University Medical Center, Seoul, Korea
Background and Purpose : The one-day rivastigmine patch is reportedly well tolerated and has minimal side effects. However, Asian patients show more side effects than those in Western countries. We evaluated tolerability of the rivastigmine patch in South Korean patients with Alzheimer’s disease (AD) and the specific factors affecting adverse events of the skin. Methods : A 6-month, open labeled, multi-centered, observational study was carried out in 440 patients with probable AD from July 2009 to September 2010 (NCT01312363). Results : A total of 25.9% of the patients experienced adverse skin events at the rivastigmine patch application site and 17.0% discontinued treatment due to adverse events at the skin application site. The most common adverse events were itching and erythema. Patients with an allergic history and users of electric heating appliances reported skin discomfort. Older age was associated with discontinuing treatment. Conclusions : These results suggest that the rivastigmine patch induced some adverse skin events and may contribute to understanding and improving skin tolerability to the rivastigmine patch.
Key Words: rivastigmine transdermal patch, Alzheimer’s disease, tolerability.
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