- 학회지
권호별 검색
- 현재 페이지 경로
-
- HOME
- 학회지
- 학회지
- 권호별 검색
| Original Article | |||||
| Dementia and Neurocognitive Disorders 2014: 13: 4: 112-116 | |||||
| CADASIL에서 고혈압이 열공경색과 뇌미세출혈의 발병위치에 미치는 영향 | |||||
|---|---|---|---|---|---|
| 이정석·오정환·송숙근, 최재철·강사윤·강지훈 | |||||
| 제주대학교병원 신경과 | |||||
| Topographical Distribution of Lacunes and Cerebral Microbleeds in CADASIL Affected by Hypertension | |||||
| Jung Seok Lee, M.D., Jung-Hwan Oh, M.D., Sook Keun Song, M.D., Jay Chol Choi, M.D.,Sa-Yoon Kang, M.D., Ji-Hoon Kang, M.D. | |||||
| Department of Neurology, Jeju National University Hospital, Jeju, Korea | |||||
| Background: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited small vessel disease caused by mutations in the Notch3 gene. Lacunes may reflect occlusive type microangiopathy. However, cerebral microbleeds (CMBs) may reflect bleeding-prone microangiopathy. In the present study, we aimed to determine whether hypertension influence the distribution and severity of lacunes and CMBs in patients with CADASIL. Methods: The study population comprised 85 patients who underwent brain MRI, including T1-weighted image, susceptibility weighted image (SWI), and fluid attenuated inversion recovery (FLAIR) image. The patients were divided into two groups depending on the presence or absence of hypertension. In the first, demographic factors, and MRI findings were compared between CADASIL patients with and without hypertension. In the second, we undertook a region by region comparison of number of patients with lacunes or CMBs. Results: The hypertensive group showed a higher incidence of CMBs in lobar area (p<0.001) and basal ganglia (p=0.014). CMBs tend to be observed more frequently in the thalamus (p=0.058), brainstem (p=0.057), and cerebellum (p=0.052) in the hypertensive group. However, hypertensive group demonstrated a higher incidence of lacunes just in lobar area (p=0.040). Conclusions: Our findings suggest that CMBs may be a more sensitive neuroimaging marker of hypertensive arteriopathy in patients with CADASIL. | |||||
| Key Words: Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), Hypertension, Lacunes, Cerebral microbleeds (CMBs) | |||||
| 대한치매학회지 (Dementia and Neurocognitive Disorders) |
|||||
- Sponsor
-
- Tel : +82-2-587-7462
- Fax : +82-2-587-7482
- e-mail : secretkda@thedementia.co.kr
- 사업자등록번호 : 214-82-63838
- 상호 : 대한치매학회
- 대표자명 : 최성혜 이사장
Copyright © The Korean Dementia Association, All rights reserved