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Review
Dementia and Neurocognitive Disorders 2014: 13: 2: 27-36	전문보기
곽용태*, 양영순†, 구민성‡
용인효자병원 신경과*, 보훈공단 중앙보훈병원 신경과†, 관동대학교 정신과교실‡
Depression in Alzheimer’s Disease
Yong Tae Kwak, M.D.*, YoungSoon Yang, M.D.†, Min-Seong Koo, M.D.‡
Department of Neurology*, Hyoja Geriatric Hospital, Yongin; Department of Neurology†, Seoul Veterans Hospital, Seoul; Department of Psychiatry‡, College of Medicine, Kwandong University, Gangnung, Korea
Depression is one of the most common psychiatric complications of Alzheimer disease (AD), affecting from 30% to 50% of prevalence, with most estimates in the 20-30% range. Because of having a presentation in the context of AD that differs from typical early-onset depression, it is not easy one to detect and quantify reliably, and can be difficulty to differentiate depression from the other neuropsychiatric symptoms of AD. Due to the lack of large randomized trials, optimal treatment and the true degree of efficacy remains undetermined. However, these treatments can reduce adverse impact of depression on patients and caregivers. This article provides a practical discussion of the diagnosis, evaluation, differential diagnosis and treatment of depression in AD for the clinician.
Key Words: Depression, Alzheimer’s disease, Early-onset depression
대한치매학회지 (Dementia and Neurocognitive Disorders)