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| Original Article | |||||
| Dementia and Neurocognitive Disorders 2012: 11: 4: 141-145 | |||||
| 오각형 그리기와 관련된 대뇌 회색질 영역 | |||||
|---|---|---|---|---|---|
| 이익성·홍윤정*·윤보라†·임성철‡·심용수‡·안국진§·조아현‡·양동원‡ | |||||
| 한국과학기술원 의과학대학원, *효자병원, †건양대학교 의과대학 신경과학교실, ‡가톨릭대학교 의과대학 신경과학교실, §영상의학과학교실 | |||||
| Anatomical Correlates of Interlocking Pentagon Drawing | |||||
| Eek-Sung Lee, M.D., Yun Jeong Hong, M.D.*, Bora Yoon, M.D.†, Sung-Chul Lim, M.D.‡, Yong S. Shim, M.D.‡, Kook Jin Ahn, M.D.§, A-Hyun Cho, M.D.‡, Dong-Won Yang, M.D.‡ | |||||
| Graduate School of Medical Science and Engineering, KAIST, Daejeon; *Hyoja Geriatric Hospital, Yongin; †Department of Neurology, Konyang University College of Medicine, Daejeon; ‡Departments of Neurology, §Radiology, College of Medicine, The Catholic University of Korea, Seoul, Korea | |||||
| Background: The interlocking pentagon drawing test, a part of the Mini-Mental State Examination (MMSE), is a widely used clinical practice to measure visuoconstructional ability of dementia patients. We investigated the anatomical structures of brain associated with pentagon drawing in subjects with mild to moderate Alzheimer’s disease (AD) by using voxel-based morphometry (VBM). Methods: Medical records of forty-four AD patients were reviewed and a 1.5 T SPGR 3D image data were used for VBM analysis. A voxel-based multiple regression analysis was used to investigate correlation between gray matter loss and pentagon drawing performance of AD patients. The correlations between pentagon drawing score and MMSE score were evaluated by Spearman correlation analysis. Results: There was a positive correlation between the interlocking pentagon copying scores and the MMSE scores (r=0.448, p=0.002). The lower the scores of interlocking pentagon copying were, the more severe the atrophy of right inferior frontal gyrus became ([x, y, z]=[52, 39, 3], Broadmann area 45, and z score=3.86). Conclusions: The performance of interlocking pentagon drawing is associated with a general cognitive function in patients with mild-to-moderate Alzheimer’s disease. It is also associated with the atrophy of the right inferior frontal gyrus. | |||||
| Key Words: Interlocking pentagon drawing, Right inferior frontal gyrus, Voxel-based morphometry, Alzheimer’s disease | |||||
| 대한치매학회지 (Dementia and Neurocognitive Disorders) |
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