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| Review | |||||
| Dementia and Neurocognitive Disorders 2012: 11: 4: 111-117 | |||||
| 비타민 D 결핍과 인지장애 | |||||
|---|---|---|---|---|---|
| 문연실*·한설희*,† | |||||
| 건국대학교병원*, 건국대학교 의학전문대학원 신경과학교실† | |||||
| Vitamin D Deficiency and Cognitive Dysfunction | |||||
| Yeonsil Moon, M.D.*, Seol-Heui Han, M.D.*,† | |||||
| Department of Neurology, Konkuk University Medical Center*, Konkuk University School of Medicine†, Seoul, Korea | |||||
| Vitamin D is not a true vitamin but a fat-soluble steroid prohormone that has long been known for its important and diverse role in the biological system. Many studies have revealed that vitamin D deficiency is linked with an increased risk of autoimmune diseases, cardiovascular diseases, cancers, type II diabetes and infectious diseases. Vitamin D3 is transformed to its active form, 1, 25-dihydroxyvitamin D3, through metabolisms in the liver and kidney. 1, 25-dihydroxyvitamin D3 interacts with its vitamin D receptor, and the brain is now known to have vitamin D receptors and 1α-hydroxylase. Several lines of evidences suggest vitamin D deficiency is associated with cognitive impairment and dementia, however, its position in cognitive function is still in its infancy. Vitamin D deficiency is a reversible condition and can be easily treated with supplements. Randomized controlled trials of vitamin D supplementation in patients with neurodegenerative conditions are needed. | |||||
| Key Words: Vitamin D deficiency, Cognition, Alzheimer’s disease (AD) | |||||
| 대한치매학회지 (Dementia and Neurocognitive Disorders) |
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