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| Original Article | |||||
| Dementia and Neurocognitive Disorders 2012: 11: 2: 67-73 | |||||
| The Correlation of the White Matter Lesions and Lacunar Infarcts in Patients with Vascular Cognitive Impairment | |||||
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| The Correlation of the White Matter Lesions and Lacunar Infarcts in Patients with Vascular Cognitive Impairment | |||||
| Heeyoung Kim, M.D., EunHye Jeong, M.D., Rahyeong Juh, Ph.D,*Jae-Hong Lee, M.D. | |||||
| Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul; Department of Neurosurgery*, Seoul National University College of Medicine, Seongnam, Korea | |||||
| Background: Cerebral white matter lesions (WMLs) and lacunar infarcts (LIs) are mostly caused by small vessel disease (SVD). Whereas the main pathomechanism behind LIs is SVD, a variety of mechanisms could be responsible for WMLs. We tried to investigate the relationship between WMLs and LIs and the impact of subtypes of WMLs on its relationship. Methods: We assessed 128 subjects with vascular cognitive impairment with subcortical vascular lesion (VCI-S). LI number and WML volume were determined on T1-, T2-weighted images and fluid-attenuated inversion recovery images using a semiquantitative visual scale. Cognitive function and daily functional impairment were assessed with Mini-Mental State Examination (MMSE) and the Seoul-Instrumental Activities of Daily Living (S-IADL). Results: Of the 128 patients, 106 (82.8%) had Alzheimer’s disease with WML and 22 (17.2%) had subcortical vascular dementia. Seventy patients (54.7%) had at least one lacune. A univariate Poisson model showed that history of hypertension, history of stroke and WML volume (periventricular and deep subcortical) were associated with LIs. A multivariate Poisson model showed that increased WML volume of both types and history of hypertension were associated with LIs. Neither S-IADL score nor MMSE was significantly associated with WML volume of both types. Conclusions: We found that LIs were associated with WMLs regardless of their types in patients with VCI-S. These findings may suggest that periventricular and deep subcortical WMLs share the same vascular pathomechanism of SVD as LIs. | |||||
| Key Words: White matter lesions, Lacunar infarction, Vascular cognitive impairment | |||||
| 대한치매학회지 (Dementia and Neurocognitive Disorders) |
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