- 학회지
권호별 검색
- 현재 페이지 경로
-
- HOME
- 학회지
- 학회지
- 권호별 검색
| Original Article | |||||
| Dementia and Neurocognitive Disorders 2011: 10: 4: 107-111 | |||||
| Regional Metabolic Changes using Proton Magnetic Resonance Spectroscopy in Patients with Amnestic Mild Cognitive Impairment | |||||
|---|---|---|---|---|---|
| Hyoung Suk Han, M.D.*,Jung Hyun Joo, M.D.†,Soo Shin Park, M.D., Jin Sung Cheong, M.D., Yoon Su Ha, M.D., Hak Seung Lee, M.D., HyunYoung Park, M.D., Hyuk Chang, M.D. | |||||
| Department of Neurology, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science, Iksan; Departments of Neurology* and Radiology†, St. Carollo Hospital, Suncheon, Korea | |||||
| Regional Metabolic Changes using Proton Magnetic Resonance Spectroscopy in Patients with Amnestic Mild Cognitive Impairment | |||||
| Hyoung Suk Han, M.D.*,Jung Hyun Joo, M.D.†,Soo Shin Park, M.D., Jin Sung Cheong, M.D., Yoon Su Ha, M.D., Hak Seung Lee, M.D., HyunYoung Park, M.D., Hyuk Chang, M.D. | |||||
| Department of Neurology, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science, Iksan; Departments of Neurology* and Radiology†, St. Carollo Hospital, Suncheon, Korea | |||||
| Background: Amnestic mild cognitive impairment (aMCI) is thought to be a prodromal stage of Alzheimer disease (AD). It is very important to diagnose aMCI for early treatment. Magnetic resonance spectroscopy (MRS) is a non-invasive technique for measuring intracerebral metabolites for early detection of cognitive decline. We measured regional metabolic changes in aMCI and healthy control (HC) subjects to assess the disease progression by using 1H-MRS. Methods: We studied 9 subjects who met the criteria for aMCI and 10 HC subjects. We measured the ratio of N-acetylaspartate (NAA), myo-inositol (mI), and choline (Cho) to creatine (Cr) in hippocampus and posterior cingulate gyrus. Results: There was a significant elevation of the mI/Cr ratio in the hippocampus (p<0.05). However, there were no significant differences in NAA/Cr and Cho/Cr ratios in the left hippocampus and left posterior cingulated gyrus. Also, there was no significant difference in the mI/Cr ratio in the left posterior cingulated gyrus. Conclusions: Using 1H-MRS, we revealed that there is a difference in metabolic state between patients with aMCI and health controls. | |||||
| Key Words: Mild cognitive impairment, 1H-MRS, Dementia | |||||
| 대한치매학회지 (Dementia and Neurocognitive Disorders) |
|||||
- Sponsor
-
- Tel : +82-2-587-7462
- Fax : +82-2-587-7482
- e-mail : secretkda@thedementia.co.kr
- 사업자등록번호 : 214-82-63838
- 상호 : 대한치매학회
- 대표자명 : 양동원 이사장
Copyright © The Korean Dementia Association, All rights reserved