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주의력 설문지 척도(Attention Questionnaire Scale)를 이용한 알츠하이머병과 피질하혈관성치매 환자의 피질하 고신호병변에 따른 주의집중력의 차이
Original Article
Dementia and Neurocognitive Disorders 2011: 10: 3: 80-87	전문보기
구본대*, 김상윤†
관동대학교 의과대학 명지병원 신경과*, 서울대학교 의과대학 신경과학교실 분당서울대학교병원 신경과†
Attentional Differences according to the Subcortical White Matter Hyperintensities in Patients with Alzheimer Disease and Subcortical Vascular Dementia using Attention Questionnaire Scale
Bon D. Ku, M.D.*, SangYun Kim, M.D.†
Department of Neurology*, Myongji Hospital, Kwandong University College of Medicine, Goyang; Department of Neurology†, Seoul National University Bundang Hospital & Seoul National University College of Medicine, Seongnam, Korea
Background: Attention is too difficult to measure quantification due to the numerous affected variables. Attention Questionnaire Scale (AQS) is a newly developed scale for the evaluation of the patient’s attention. The aim of this study was to adapt AQS to evaluate the correlation between attention and subcortical hyperintensities (SH) to the patients with mild to moderate Alzheimer disease (AD) or subcortical vascular dementia (SVD). Methods: Patients with mild to moderate AD or SVD were recruited from March 2008 to February 2010. On magnetic resonance imaging, deep white matter (DWM) yperintensities were classified into D1 (the longest diameter of DWM lesion <10 mm), D2 (10 mm≤DWM≤24 mm), and D3 (25 mm Results: A total of 162 study patients were recruited (87 in minimal, 22 in moderate and 53 in severe SH group). Female was predominant in all three groups (66.7%). Mean score of K-MMSE was 17.5±5.7 and that of the CDR was 1.3±0.9. Mean score of AQS was 17.1±7.9. The correlation between AQS and other scales such as K-MMSE, CDR and GDS were all significant (the correlation coefficiency was 0,317, -0.474, -0.472, respectively). Unlike other scales AQS showed significant differences between minimal and moderate or severe SH group (18.7±7.7, 15.2±6.6, 15.4±8.6, p=0.007). Conclusions: AQS is a useful dementia scale for the evaluation of the degree of SH in the patients with mild to moderate AD or SVD.
Key Words: Alzheimer disease, Subcortical vascular dementia, Attention Questionnaire Scale, Subcortical hyperintensities
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