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| Original Article | |||||
| Dementia and Neurocognitive Disorders 2011: 10: 2: 58-62 | |||||
| 알츠하이머병 환자에서의 수면구조 비교: 예비연구 | |||||
|---|---|---|---|---|---|
| 김혜윤*·김만호†·주은연‡·홍승봉‡김지영*·박종호*·한현정* | |||||
| 관동의대 명지병원 신경과*, 서울대학교병원 신경과†, 삼성서울병원 신경과‡ | |||||
| Comparative Analysis of Sleep Architecture in Alzheimer’s Disease: A Preliminary Study | |||||
| Hyeyun Kim, M.D.*, Manho Kim, M.D.†, Eun Yeon Joo, M.D.‡, Seung Bong Hong, M.D.‡, Jee Young Kim, M.D.*, Jong-Ho Park, M.D.*, Hyun Jeong Han, M.D.* | |||||
| Department of Neurology*, Myongji Hospital Kwandong University College of Medicine, Gangneung; Department of Neurology†, Seoul National University Hospital, Seoul; Department of Neurology‡, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea | |||||
| Background: Prevalence of sleep problems has been estimated to 25-35% in patients with probable Alzheimer’s disease (AD). The aim of this study was to estimate differences of sleep architecture and variable parameters between patients with probable AD and healthy control (HC). Methods: Fourteen patients with probable AD and 12 HC were retrospectively analyzed sleep parametes and architectures. Overnight polysomnography (PSG) and sleep questionnaires including Epworth sleepiness scale (ESS), Beck Depression Inventory (BDI) were performed for analyze sleep quality, structure and related problems. Dementia severity was assessed with Korean version of Mini-mental State Examination and Korean version of expended Clinical Dementia Rating. The sleep variables included proportions of rapid eye movement (REM) sleep, non-REM sleep such as N1, N2, and N3, total sleep time (TST), sleep efficiency (SE), wake after sleep onset (WASO), Periodic limbs movement during sleep (PLMS) index, respiratory disturbance index (RDI), latency to sleep onset were conducted. Results: RDI and WASO in AD was significantly higher than HC (p<0.05). TST, the proportion of N2, and N3 sleep were decreased and N1 was marked increased in AD group. The quality of REM sleep was not significantly different between HC and AD group. Conclusions: AD presented worse sleep qualities than HC in overnight PSG. These results support the hypothesis that obstructive sleep apnea is associated with AD pathology. | |||||
| Key Words: Sleep, Respiratory disturbance index, Polysomnography, Alzheimer’s disease | |||||
| 대한치매학회지 (Dementia and Neurocognitive Disorders) |
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