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| Original Article | |||||
| Dementia and Neurocognitive Disorders 2010: 9: 4: 107-114 | |||||
| 알츠하이머병 진행에 따른 해마의 기능적 연결 변화: FDG-PET을 이용한 뇌 영역간 상관분석 | |||||
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| 조상수∙김은주*∙강수진∙이병화†·김상은∙나덕렬†· | |||||
| 서울대학교 의과대학 분당서울대학교병원 핵의학과, 부산대학교 의과대학 신경과학교실* 성균관대학교 의과대학 삼성서울병원 신경과† |
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| Changes in Functional Connectivity of Hippocampus during the Progress of Alzheimer Disease: Interregional Correlation Analysis Using FDG-PET | |||||
| Sang Soo Cho, Ph.D., Eun-Joo Kim, M.D, Ph.D.*, Sue J. Kang, M.S.†,Byung Hwa Lee, M.A.†, Sang Eun Kim, M.D., Ph.D., Duk L. Na, M.D., Ph.D.† | |||||
| Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National
University College of Medicine, Seongnam; Department of Neurology*, Pusan National University School of Medicine and Medical Research Institute, Busan; Department of Neurology†, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea |
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| Background: Deficit of memory function is a main symptom found in Alzheimer disease (AD) even in the early stage of disease. Since the hippocampus is a critical area for memory function, hippocampal atrophy can serve as a biomarker of AD. To identify whether the hippocampus connectivity may change as the disease progress in patients with AD, interregional-connectivity analysis were conducted using [18F]fluorodeoxyglucose (FDG)-positron emission tomography (PET) and statistical parametric mapping (SPM). Methods: We examined metabolic correlation of the hippocampus using a sample of 72 AD patients who had undergone FDG-PET. Count normalized regional FDG activities were extracted from left and right hippocampi using the pre-identified region of interest (ROI) by automated anatomical labeling (AAL) and MarsBar toolbox implanted in SPM2. Inter-regional analyses using the left or right hippocampus as seeds were conducted in each CDR group (0.5, 1, and 2/3). Normalized mean radioactive counts from left or right hippocampus were used as independent variables in a general linear model to search for voxels correlated with seed area across the whole brain. Results: In CDR 0.5 group, both left and right hippocampal seeds yielded correlations that were limited to themselves; there was no correlation in contralateral homologous regions or any other cortical/subcortical regions. In CDR 1 group, however, the left and right hippocampal seeds yielded positive correlation in ipsilateral temporal cortex, visual cortex and frontal motor areas. In CDR 2/3 group, distinctive hippocampal metabolic connectivity patterns in each hemisphere were found. Left hippocampal seed yielded correlations that were limited to itself, while right hippocampus showed enlarged correlations in temporal cortex and occipital visual cortex as well as frontal cortex including orbitofrontal cortex and basal ganglia. Conclusions: The changes in the hippocampal communication loop we observed in this study may reflect changes in local neuroplasticity according to the progression of AD. Our results may have implication for understanding the decline and compensation mechanism of memory function in AD patients. | |||||
| Key Words: Alzheimer disease (AD), Hippocampus, Regional Cerebral Glucose Metabolism, | |||||
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