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| Original Article | |||||
| Dementia and Neurocognitive Disorders 2007: 6: 2: 29-33 | |||||
| 기억성 경도인지장애와 초기 알츠하이머병에서의 국소뇌혈류 변화 | |||||
|---|---|---|---|---|---|
| 심용수∙양동원∙김범생∙정용안* | |||||
| 가톨릭대학교 의과대학 신경과학교실 핵의학교실* |
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| Regional Cerebral Blood Flow Patterns in Amnestic Mild Cognitive Impairment and Early Alzheimer’s Disease | |||||
| Yong Soo Shim, M.D., Dong-Won Yang, M.D., Beum-Saeng Kim, M.D., Yong-Ahn Chung, M.D.* | |||||
| Departments of Neurology and Nuclear Medicine*, College of Medicine, The Catholic University of Korea, Seoul, Korea | |||||
| Background: Amnestic mild cognitive impairment (aMCI) is an intermediary state between normal aging and Alzheimer’s disease (AD). Previous studies have shown that most of the aMCI patients have histopathologic changes compatible with AD. We studied patterns of regional cerebral blood flow (rCBF) in aMCI and early AD with statistical parametric mapping (SPM) analysis of 99mTc-ECD single photon emission computed tomography (SPECT) to estimate the functional abnormality in two groups. Methods: Eighteen subjects with early AD (male 7, female 11, age 69.60±76.78) and 16 subjects with aMCI (male 6, female 10, age 69.19±7.13) were recruited. ECD-SPECT was performed in two groups and 14 age-matched normal controls, and SPM analysis was conducted to identify brain regions with decreased rCBF in each groups. Results:Significantly decreased rCBF was observed in the left inferior temporal, thalamus, superior temporal, and bilateral prefrontal and parietal areas in the aMCI group as compared to normal controls. In the early AD group, similar patterns of decreased rCBF were observed. The early AD group had greater decreased rCBF in the left superior prefrontal area as compared to the aMCI group. Conclusions: Although aMCI is an intermediary state between normal aging and AD, cerebral function measured by rCBF in aMCI was already decreased to a similar extent of that observed in early AD. The early AD group had a greater decreased rCBF in the superior prefrontal area, which is probably associated with impairment in the activities of daily living. | |||||
| Key Words: Mild cognitive impairment, Alzheimer’s disease, SPECT, Statistical parametric mapping | |||||
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