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Original Article
2025; 24 209 - 232
Executive Summary of 2025 International Conference of the Korean Dementia Association and International Congress of the Asian Society Against Dementia (IC-KDA/ASAD 2025): A Report From the Academic Committee of the Korean Dementia Association

Jaeho Kim ,1 Geon Ha Kim ,2 Kyunghun Kang ,3 Hee Jin Kim ,4 Jeewon Suh ,5 Bora Yoon ,6 Hanna Cho ,7 Jung-Min Pyun ,8 Young Ho Park ,8 Han Kyoung Choe ,9 Yun Kyung Kim ,10 Kun Ho Lee ,11 Jae Gwan Kim ,12 Soh-Jeong Yang ,13 Min Jae Baek ,8 Juhee Chin ,14 Hyemin Jang ,15 So Young Moon ,16 on behalf of Academic Committee of the Korean Dementia Association
1 Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea 2 Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University, College of Medicine, Seoul, Korea 3Department of Neurology, School of Medicine, Kyungpook National University, Daegu, Korea 4 Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 5Department of Neurology, Dongguk University Ilsan Hospital, Goyang, Korea 6 Department of Neurology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea 7 Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea 8 Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea 9 Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Korea 10Brain Science Institute, Korea Institute of Science and Technology, Seoul, Korea 11Department of Biomedical Science, Chosun University, Gwangju, Korea 12 Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Korea 13Department of Neurology, Severance Hospital of Yonsei University Health System, Seoul, Korea 14Department of Psychology, College of Social Sciences, Hallym University, Chuncheon, Korea 15Department of Neurology, Asan Medical Center, Seoul, Korea 16Department of Neurology, Ajou University School of Medicine, Suwon, Korea

Jaeho Kim ,1 Geon Ha Kim ,2 Kyunghun Kang ,3 Hee Jin Kim ,4 Jeewon Suh ,5 Bora Yoon ,6 Hanna Cho ,7 Jung-Min Pyun ,8 Young Ho Park ,8 Han Kyoung Choe ,9 Yun Kyung Kim ,10 Kun Ho Lee ,11 Jae Gwan Kim ,12 Soh-Jeong Yang ,13 Min Jae Baek ,8 Juhee Chin ,14 Hyemin Jang ,15 So Young Moon ,16 on behalf of Academic Committee of the Korean Dementia Association
1 Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea 2 Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University, College of Medicine, Seoul, Korea 3Department of Neurology, School of Medicine, Kyungpook National University, Daegu, Korea 4 Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 5Department of Neurology, Dongguk University Ilsan Hospital, Goyang, Korea 6 Department of Neurology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea 7 Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea 8 Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea 9 Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Korea 10Brain Science Institute, Korea Institute of Science and Technology, Seoul, Korea 11Department of Biomedical Science, Chosun University, Gwangju, Korea 12 Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Korea 13Department of Neurology, Severance Hospital of Yonsei University Health System, Seoul, Korea 14Department of Psychology, College of Social Sciences, Hallym University, Chuncheon, Korea 15Department of Neurology, Asan Medical Center, Seoul, Korea 16Department of Neurology, Ajou University School of Medicine, Suwon, Korea

2025; 24 209 - 232
Dementia; Alzheimer Disease; Biomarkers; Neuroimaging; Neuroinflammation; Vascular Cognitive Impairment;
Original Article
2025; 24 233 - 245
Home-Based Occupational Therapy Intervention for the Improvement of Quality of Life in Individuals With Moderate to Severe Dementia and Their Caregivers

Theodosis Georgiadis ,1 Ioanna Giannoula Katsouri ,2 Charalampos Tsormpatzoudis ,3 Magdalini Tsolaki 4
1Aristotle University of Thessaloniki, Thessaloniki, Greece 2 Department of Occupational Therapy, School of Health and Care Sciences, University of West Attica (UNIWA), Athens, Greece 3 Laboratory of Humanities Research, Department of Physical Education and Sport Science, Aristotle University of Thessaloniki (TEFAA AUTh), Thessaloniki, Greece 4 Department of Neurology, Faculty of Medicine, Aristotle University of Thessaloniki (AUTh), Thessaloniki, Greece

Home-Based Occupational Therapy Intervention for the Improvement of Quality of Life in Individuals With Moderate to Severe Dementia and Their Caregivers

Theodosis Georgiadis ,1 Ioanna Giannoula Katsouri ,2 Charalampos Tsormpatzoudis ,3 Magdalini Tsolaki 4
1Aristotle University of Thessaloniki, Thessaloniki, Greece 2 Department of Occupational Therapy, School of Health and Care Sciences, University of West Attica (UNIWA), Athens, Greece 3 Laboratory of Humanities Research, Department of Physical Education and Sport Science, Aristotle University of Thessaloniki (TEFAA AUTh), Thessaloniki, Greece 4 Department of Neurology, Faculty of Medicine, Aristotle University of Thessaloniki (AUTh), Thessaloniki, Greece

2025; 24 233 - 245
Dementia; Activities of Daily Living; Occupational Therapy; Home Care Services; Quality of Life;
Original Article
2025; 24 246 - 258
Mendelian Randomization Reveals Unidirectional Links Between Amyloid-β and Tau in Alzheimer’s Disease

Jun Pyo Kim ,1,* Hyunwoo Lee ,2,3,* Bo-Hyun Kim ,2 Kwangsik Nho ,4 Shannon L Risacher ,4 Andrew J Saykin ,4 Sang Won Seo ,1,2 Han-Na Kim 5,6
1 Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 2Alzheimer's Disease Convergence Research Center, Samsung Medical Center, Seoul, Korea 3 Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul, Korea 4 Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA 5 Department of Clinical Research Design & Evaluation, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Korea 6Center for Clinical Epidemiology, Samsung Medical Center, Sungkyunkwan University, Seoul, Korea

Mendelian Randomization Reveals Unidirectional Links Between Amyloid-β and Tau in Alzheimer’s Disease

Jun Pyo Kim ,1,* Hyunwoo Lee ,2,3,* Bo-Hyun Kim ,2 Kwangsik Nho ,4 Shannon L Risacher ,4 Andrew J Saykin ,4 Sang Won Seo ,1,2 Han-Na Kim 5,6
1 Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 2Alzheimer's Disease Convergence Research Center, Samsung Medical Center, Seoul, Korea 3 Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul, Korea 4 Center for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA 5 Department of Clinical Research Design & Evaluation, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Korea 6Center for Clinical Epidemiology, Samsung Medical Center, Sungkyunkwan University, Seoul, Korea

2025; 24 246 - 258
Alzheimer's Disease; Amyloid Beta-Peptides; Tau Proteins; Positron-Emission Tomography; Cerebrospinal Fluid; Genome-Wide Association Study;
Original Article
2025; 24 259 - 271
Gait Patterns and Balance Impairment in Parkinson’s Disease With Correlation to Disease Severity

Danyeong Kim ,1,2 Da-Eun Jeong ,1 Hyunkyung Yi ,3 Min Ju Kang 1
1 Department of Neurology, Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul, Korea 2Department of Bionano Technology, Gachon University, Seongnam, Korea 3 Department of Nuclear Medicine, Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul, Korea

Gait Patterns and Balance Impairment in Parkinson’s Disease With Correlation to Disease Severity

Danyeong Kim ,1,2 Da-Eun Jeong ,1 Hyunkyung Yi ,3 Min Ju Kang 1
1 Department of Neurology, Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul, Korea 2Department of Bionano Technology, Gachon University, Seongnam, Korea 3 Department of Nuclear Medicine, Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul, Korea

2025; 24 259 - 271
Parkinson Disease; Gait, Biomarker; Disease Progression;
Original Article
2025; 24 272 - 285
Mesenchymal Stem Cells With Adjuvant Dexamethasone in Patients With Alzheimer’s Disease: A Phase IIa Trial

Na Kyung Lee ,1,2,* Hyemin Jang ,3,4,5,* Yejoo Choi,2 Song Hwangbo,4,5,6 Seunghoon Lee,7 Jung Il Lee ,7 Young Ju Kim,5 Juhee Chin ,5 Jong Wook Chang ,1,2 Sang Won Seo ,1,4,5,8,9 Hyo Jin Son ,2,4,5 Soo Jin Choi,10 Duk L. Na ,2,4,5,11 Hee Jin Kim 1,2,4,5,9
1 Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul, Korea 2 Cell and Gene Therapy Institute (CGTI), Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea 3Department of Neurology, Seoul National University Hospital, Seoul, Korea 4Alzheimer’s Disease Convergence Research Center, Samsung Medical Center, Seoul, Korea 5 Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 6Department of Neurology, Incheon Sejong Hospital, Incheon, Korea 7 Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 8Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Korea 9 Department of Digital Health, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul, Korea 10Biomedical Research Institute, R&D Center, MEDIPOST Co., Ltd., Seongnam, Korea 11Happymind Clinic, Seoul, Korea

Mesenchymal Stem Cells With Adjuvant Dexamethasone in Patients With Alzheimer’s Disease: A Phase IIa Trial

Na Kyung Lee ,1,2,* Hyemin Jang ,3,4,5,* Yejoo Choi,2 Song Hwangbo,4,5,6 Seunghoon Lee,7 Jung Il Lee ,7 Young Ju Kim,5 Juhee Chin ,5 Jong Wook Chang ,1,2 Sang Won Seo ,1,4,5,8,9 Hyo Jin Son ,2,4,5 Soo Jin Choi,10 Duk L. Na ,2,4,5,11 Hee Jin Kim 1,2,4,5,9
1 Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul, Korea 2 Cell and Gene Therapy Institute (CGTI), Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea 3Department of Neurology, Seoul National University Hospital, Seoul, Korea 4Alzheimer’s Disease Convergence Research Center, Samsung Medical Center, Seoul, Korea 5 Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 6Department of Neurology, Incheon Sejong Hospital, Incheon, Korea 7 Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 8Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Korea 9 Department of Digital Health, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul, Korea 10Biomedical Research Institute, R&D Center, MEDIPOST Co., Ltd., Seongnam, Korea 11Happymind Clinic, Seoul, Korea

2025; 24 272 - 285
Mesenchymal Stem Cell; Dexamethasone; Cerebrospinal Fluid; Inflammation; Cytokine;
Original Article
2025; 24 286 - 300
Clinical Utility and Diagnostic Accuracy of the Tablet-Based Seoul Cognitive Status Test: Evidence for Scalable Cognitive Assessment

Young Ju Kim ,1,* Joon Soo Shin ,1,* Dayeong An ,1,2 Duk L. Na ,1,2 Hee Jin Kim 3,4,5,6
1Beaubrain Healthcare Co., Ltd., Seoul, Korea 2Department of Neurology, Happymind Clinic, Seoul, Korea 3 Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 4Alzheimer’s Disease Convergence Research Center, Samsung Medical Center, Seoul, Korea 5Neuroscience Center, Samsung Medical Center, Seoul, Korea 6 Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul, Korea

Clinical Utility and Diagnostic Accuracy of the Tablet-Based Seoul Cognitive Status Test: Evidence for Scalable Cognitive Assessment

Young Ju Kim ,1,* Joon Soo Shin ,1,* Dayeong An ,1,2 Duk L. Na ,1,2 Hee Jin Kim 3,4,5,6
1Beaubrain Healthcare Co., Ltd., Seoul, Korea 2Department of Neurology, Happymind Clinic, Seoul, Korea 3 Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 4Alzheimer’s Disease Convergence Research Center, Samsung Medical Center, Seoul, Korea 5Neuroscience Center, Samsung Medical Center, Seoul, Korea 6 Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul, Korea

2025; 24 286 - 300
Neuropsychological Tests; Cognitive Dysfunction; Dementia; Diagnosis; Computers;
Original Article
2025; 24 301 - 310
Effects of a 12-Week Hybrid Analog–Digital Cognitive Training on Cognitively Unimpaired Older Adults: A Pilot Single-Blind Randomized Controlled Trial

Seungwon Chung ,1 Bori R. Kim ,2 Sooin Moon ,3 Geon Ha Kim 1
1 Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea 2Ewha Medical Research Institute, Ewha Womans University, Seoul, Korea 3 Division of Artificial Intelligence and Software, College of Artificial Intelligence, Ewha Womans University, Seoul, Korea

Effects of a 12-Week Hybrid Analog–Digital Cognitive Training on Cognitively Unimpaired Older Adults: A Pilot Single-Blind Randomized Controlled Trial

Seungwon Chung ,1 Bori R. Kim ,2 Sooin Moon ,3 Geon Ha Kim 1
1 Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea 2Ewha Medical Research Institute, Ewha Womans University, Seoul, Korea 3 Division of Artificial Intelligence and Software, College of Artificial Intelligence, Ewha Womans University, Seoul, Korea

2025; 24 301 - 310
Analog-Digital Conversion; Cognitive Training; Brain Training; Cambridge Neuropsychological Test Automated Battery;
Original Article
2025; 24 311 - 314
Extensive Cerebral White Matter Involvement and Migrainous Headache in a Patient With Aquaporin-4-Positive NMOSD Mimicking CADASIL

Sukyoon Lee ,1 Seong-il Oh 2
1Department of Neurology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea 2 Department of Neurology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea

Extensive Cerebral White Matter Involvement and Migrainous Headache in a Patient With Aquaporin-4-Positive NMOSD Mimicking CADASIL

Sukyoon Lee ,1 Seong-il Oh 2
1Department of Neurology, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea 2 Department of Neurology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea

2025; 24 311 - 314
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