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Original Article
2025; 24 75 - 90
Protective Genes Against Alzheimer’s Disease: Case Review and Therapeutic Implications

Nabiha Hossain ,1 Yong Jeong 1,2,3
1 Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea 2 Program of Cognitive Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea 3 KI for Health Science and Technology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea

Protective Genes Against Alzheimer’s Disease: Case Review and Therapeutic Implications

Nabiha Hossain ,1 Yong Jeong 1,2,3
1 Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea 2 Program of Cognitive Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea 3 KI for Health Science and Technology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea

2025; 24 75 - 90
Alzheimer Disease; Cognitive Reserve; Genetic Variation;
Original Article
2025; 24 91 - 101
Reproducibility of Plasma Biomarker Measurements Across Laboratories: Insights Into ptau217, GFAP, and NfL

Heekyoung Kang ,1 Sook-Young Woo ,2 Daeun Shin ,1 Sohyun Yim ,1 Eun Hye Lee ,1 Hyunchul Ryu ,3 Bora Chu ,3 Henrik Zetterberg ,4,5,6,7,8,9 Kaj Blennow ,4,5,10,11 Jihwan Yun ,12 Duk L Na ,13 Hee Jin Kim ,1,14,15,16 Hyemin Jang ,17 Jun Pyo Kim ,1 on behalf of the K-ROAD Study Groups
1 Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 2 Biomedical Statistics Center, Data Science Research Institute, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea 3DNALINK Inc., Seoul, Korea 4 Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden 5Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden 6 Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK 7UK Dementia Research Institute at UCL, London, UK 8Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, China 9 Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA 10Paris Brain Institute, ICM, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France 11 Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, and Department of Neurology, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC, Hefei, China 12Department of Neurology, Soonchunhyang University Bucheon Hospital, Bucheon, Korea 13Happymind Clinic, Seoul, Korea 14Alzheimer's Disease Convergence Research Center, Samsung Medical Center, Seoul, Korea 15Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea 16Neuroscience Center, Samsung Medical Center, Seoul, Korea 17 Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea

Reproducibility of Plasma Biomarker Measurements Across Laboratories: Insights Into ptau217, GFAP, and NfL

Heekyoung Kang ,1 Sook-Young Woo ,2 Daeun Shin ,1 Sohyun Yim ,1 Eun Hye Lee ,1 Hyunchul Ryu ,3 Bora Chu ,3 Henrik Zetterberg ,4,5,6,7,8,9 Kaj Blennow ,4,5,10,11 Jihwan Yun ,12 Duk L Na ,13 Hee Jin Kim ,1,14,15,16 Hyemin Jang ,17 Jun Pyo Kim ,1 on behalf of the K-ROAD Study Groups
1 Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 2 Biomedical Statistics Center, Data Science Research Institute, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea 3DNALINK Inc., Seoul, Korea 4 Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden 5Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden 6 Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK 7UK Dementia Research Institute at UCL, London, UK 8Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, China 9 Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA 10Paris Brain Institute, ICM, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France 11 Neurodegenerative Disorder Research Center, Division of Life Sciences and Medicine, and Department of Neurology, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC, Hefei, China 12Department of Neurology, Soonchunhyang University Bucheon Hospital, Bucheon, Korea 13Happymind Clinic, Seoul, Korea 14Alzheimer's Disease Convergence Research Center, Samsung Medical Center, Seoul, Korea 15Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea 16Neuroscience Center, Samsung Medical Center, Seoul, Korea 17 Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea

2025; 24 91 - 101
Alzheimer Disease; Biomarkers; Positron Emission Tomography; Tau Proteins; Neurofilament Proteins;
Original Article
2025; 24 102 - 114
Comprehensive Clinical and Behavioral Characteristics of Mild Cognitive Impairment According to Amyloid Positivity: A Large Multi-Center Korean Cohort

Seung Ae Kim , 1,2 Yeshin Kim ,3 Duk L. Na ,4,5 Sang Won Seo ,4,6,7,8,9 Hyemin Jang ,1 on behalf of PREMIER Consortium 
1 Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea 2Graduate School of Translational Medicine, Seoul National University College of Medicine, Seoul, Korea 3Department of Neurology, Kangwon National University College of Medicine, Chuncheon, Korea 4 Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 5Happymid Clinic, Seoul, Korea 6Alzheimer’s Disease Convergence Research Center, Samsung Medical Center, Seoul, Korea 7Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea 8Department of Digital Health, SAIHST, Sungkyunkwan University, Seoul, Korea 9Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Korea

Comprehensive Clinical and Behavioral Characteristics of Mild Cognitive Impairment According to Amyloid Positivity: A Large Multi-Center Korean Cohort

Seung Ae Kim , 1,2 Yeshin Kim ,3 Duk L. Na ,4,5 Sang Won Seo ,4,6,7,8,9 Hyemin Jang ,1 on behalf of PREMIER Consortium 
1 Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea 2Graduate School of Translational Medicine, Seoul National University College of Medicine, Seoul, Korea 3Department of Neurology, Kangwon National University College of Medicine, Chuncheon, Korea 4 Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 5Happymid Clinic, Seoul, Korea 6Alzheimer’s Disease Convergence Research Center, Samsung Medical Center, Seoul, Korea 7Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea 8Department of Digital Health, SAIHST, Sungkyunkwan University, Seoul, Korea 9Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Korea

2025; 24 102 - 114
Mild Cognitive Impairment; Amyloid; Alzheimer Disease; Cognitive Decline;
Original Article
2025; 24 115 - 125
Quantifying Brain Atrophy Using a CSF-Focused Segmentation Approach

Kyoung Yoon Lim ,1 Seongbeom Park ,1 Duk L. Na ,1 Sang Won Seo ,2,3,4,5 Min Young Chun ,6,7 Kichang Kwak ,1 on behalf of the K-ROAD study and ADNI
1BeauBrain Healthcare, Inc., Seoul, Korea 2 Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 3Alzheimer’s Disease Convergence Research Center, Samsung Medical Center, Seoul, Korea 4Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea 5Department of Digital Health, SAIHST, Sungkyunkwan University, Seoul, Korea 6Department of Neurology, Yonsei University College of Medicine, Seoul, Korea 7Depeartment of Neurology, Yongin Severance Hospital, Yonsei University Health System, Yongin, Korea

Quantifying Brain Atrophy Using a CSF-Focused Segmentation Approach

Kyoung Yoon Lim ,1 Seongbeom Park ,1 Duk L. Na ,1 Sang Won Seo ,2,3,4,5 Min Young Chun ,6,7 Kichang Kwak ,1 on behalf of the K-ROAD study and ADNI
1BeauBrain Healthcare, Inc., Seoul, Korea 2 Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 3Alzheimer’s Disease Convergence Research Center, Samsung Medical Center, Seoul, Korea 4Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea 5Department of Digital Health, SAIHST, Sungkyunkwan University, Seoul, Korea 6Department of Neurology, Yonsei University College of Medicine, Seoul, Korea 7Depeartment of Neurology, Yongin Severance Hospital, Yonsei University Health System, Yongin, Korea

2025; 24 115 - 125
Alzheimer Disease; Neurodegenerative Diseases; Atrophy; Cerebrospinal Fluid; Deep Learning; Magnetic Resonance Imaging;
Original Article
2025; 24 126 - 134
Cognitive Impairment Screening Test in Korea as a Screening Tool for Dementia: The Correlation Study of Subtest Scores With Korean Version of the Mini Mental State Examination 2nd Edition

Minseong Kim ,1 Doyun Heo ,1 Seonkyeong Kim ,1 Yunjin Lee ,1 Yong Sung Kim ,2 Wonjae Sung ,2 Hee-Jin Kim ,2
1Department of Neurology, College of Medicine, Hanyang University, Seoul, Korea 2 Department of Neurology, Hanyang University Seoul Hospital, College of Medicine, Hanyang University, Seoul, Korea

Cognitive Impairment Screening Test in Korea as a Screening Tool for Dementia: The Correlation Study of Subtest Scores With Korean Version of the Mini Mental State Examination 2nd Edition

Minseong Kim ,1 Doyun Heo ,1 Seonkyeong Kim ,1 Yunjin Lee ,1 Yong Sung Kim ,2 Wonjae Sung ,2 Hee-Jin Kim ,2
1Department of Neurology, College of Medicine, Hanyang University, Seoul, Korea 2 Department of Neurology, Hanyang University Seoul Hospital, College of Medicine, Hanyang University, Seoul, Korea

2025; 24 126 - 134
Cognitive Impairment Screening Test in Korea; Cognitive Assessment Screening Instrument; Korean Version of the Mini Mental State Examination 2nd Edition;
Original Article
2025; 24 135 - 146
Establishing Regional Aβ Cutoffs and Exploring Subgroup Prevalence Across Cognitive Stages Using BeauBrain Amylo®

Seongbeom Park ,1,* Kyoungmin Kim ,2,* Soyeon Yoon ,2 Seongmi Kim ,2 Jehyun Ahn ,2 Kyoung Yoon Lim ,1 Hyemin Jang ,3 Duk L. Na ,1,4 Hee Jin Kim ,2,5,6,7,8 Seung Hwan Moon ,9 Jun Pyo Kim ,5 Sang Won Seo ,2,5,6,7,8 Jaeho Kim ,10 Kichang Kwak  1
1BeauBrain Healthcare, Inc., Seoul, Korea 2Alzheimer's Disease Convergence Research Center, Samsung Medical Center, Seoul, Korea 3 Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea 4Department of Neurology, Happymind Clinic, Seoul, Korea 5 Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 6 Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea 7Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Korea 8 Department of Digital Health, SAIHST, Sungkyunkwan University, Seoul, Korea 9 Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 10 Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea

Establishing Regional Aβ Cutoffs and Exploring Subgroup Prevalence Across Cognitive Stages Using BeauBrain Amylo®

Seongbeom Park ,1,* Kyoungmin Kim ,2,* Soyeon Yoon ,2 Seongmi Kim ,2 Jehyun Ahn ,2 Kyoung Yoon Lim ,1 Hyemin Jang ,3 Duk L. Na ,1,4 Hee Jin Kim ,2,5,6,7,8 Seung Hwan Moon ,9 Jun Pyo Kim ,5 Sang Won Seo ,2,5,6,7,8 Jaeho Kim ,10 Kichang Kwak  1
1BeauBrain Healthcare, Inc., Seoul, Korea 2Alzheimer's Disease Convergence Research Center, Samsung Medical Center, Seoul, Korea 3 Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea 4Department of Neurology, Happymind Clinic, Seoul, Korea 5 Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 6 Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea 7Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Korea 8 Department of Digital Health, SAIHST, Sungkyunkwan University, Seoul, Korea 9 Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 10 Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea

2025; 24 135 - 146
Alzheimer Disease; Tomography, X-Ray Computed; Positron-Emission Tomography; Cognition Disorders; Amyloid Plaques;