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Original Article
2025; 24 1 - 23
Clinical Practice Guidelines for Dementia: Recommendations for Cholinesterase Inhibitors and Memantine

Yeshin Kim ,1 Dong Woo Kang ,2 Geon Ha Kim ,3 Ko Woon Kim ,4 Hee-Jin Kim ,5 Seunghee Na ,6 Kee Hyung Park ,7 Young Ho Park ,8 Gihwan Byeon ,2 Jeewon Suh ,9 Joon Hyun Shin ,10 YongSoo Shim ,11 YoungSoon Yang ,12 Yoo Hyun Um ,13 Seong-il Oh ,14 Sheng-Min Wang ,15 Bora Yoon ,16 Sun Min Lee ,17 Juyoun Lee ,18 Jin San Lee ,14 Jae-Sung Lim ,19 Young Hee Jung ,20 Juhee Chin ,21 Hyemin Jang ,22 Miyoung Choi ,23 Yun Jeong Hong ,24 Hak Young Rhee ,25 Jae-Won Jang ,1 on behalf of Korean Dementia Association
1 Department of Neurology, Kangwon National University Hospital, Kangwon National University College of Medicine, Chuncheon, Korea 2 Department of Psychiatry, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea 3 Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea 4 Department of Neurology, Jeonbuk National University Medical School and Hospital, Jeonju, Korea 5 Department of Neurology, Hanyang University Hospital, College of Medicine, Hanyang University, Seoul, Korea 6 Department of Neurology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea 7Department of Neurology, College of Medicine, Gachon University Gil Medical Center, Incheon, Korea 8 Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea 9Department of Neurology, National Medical Center, Seoul, Korea 10Dr Shin’s Neurology Clinic, Wonju, Korea 11 Department of Neurology, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea 12 Department of Neurology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University School of Medicine, Cheonan, Korea 13 Department of Psychiatry, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea 14 Department of Neurology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea 15 Department of Psychiatry, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea 16 Department of Neurology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea 17 Department of Neurology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea 18 Department of Neurology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea 19Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea 20 Department of Neurology, Hallym Sacred Heart Hospital, College of Medicine, Hallym University, Anyang, Korea 21Department of Psychology, Doheon Academy Hallym University, Chuncheon, Korea 22Department of Neurology, Seoul National University Hospital, Seoul, Korea 23 Division of Healthcare Technology Assessment Research, National Evidence-based Healthcare Collaborating Agency, Seoul, Korea 24 Department of Neurology, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea 25 Department of Neurology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, Korea

Clinical Practice Guidelines for Dementia: Recommendations for Cholinesterase Inhibitors and Memantine

Yeshin Kim ,1 Dong Woo Kang ,2 Geon Ha Kim ,3 Ko Woon Kim ,4 Hee-Jin Kim ,5 Seunghee Na ,6 Kee Hyung Park ,7 Young Ho Park ,8 Gihwan Byeon ,2 Jeewon Suh ,9 Joon Hyun Shin ,10 YongSoo Shim ,11 YoungSoon Yang ,12 Yoo Hyun Um ,13 Seong-il Oh ,14 Sheng-Min Wang ,15 Bora Yoon ,16 Sun Min Lee ,17 Juyoun Lee ,18 Jin San Lee ,14 Jae-Sung Lim ,19 Young Hee Jung ,20 Juhee Chin ,21 Hyemin Jang ,22 Miyoung Choi ,23 Yun Jeong Hong ,24 Hak Young Rhee ,25 Jae-Won Jang ,1 on behalf of Korean Dementia Association
1 Department of Neurology, Kangwon National University Hospital, Kangwon National University College of Medicine, Chuncheon, Korea 2 Department of Psychiatry, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea 3 Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea 4 Department of Neurology, Jeonbuk National University Medical School and Hospital, Jeonju, Korea 5 Department of Neurology, Hanyang University Hospital, College of Medicine, Hanyang University, Seoul, Korea 6 Department of Neurology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea 7Department of Neurology, College of Medicine, Gachon University Gil Medical Center, Incheon, Korea 8 Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea 9Department of Neurology, National Medical Center, Seoul, Korea 10Dr Shin’s Neurology Clinic, Wonju, Korea 11 Department of Neurology, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea 12 Department of Neurology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University School of Medicine, Cheonan, Korea 13 Department of Psychiatry, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea 14 Department of Neurology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea 15 Department of Psychiatry, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea 16 Department of Neurology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea 17 Department of Neurology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea 18 Department of Neurology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea 19Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea 20 Department of Neurology, Hallym Sacred Heart Hospital, College of Medicine, Hallym University, Anyang, Korea 21Department of Psychology, Doheon Academy Hallym University, Chuncheon, Korea 22Department of Neurology, Seoul National University Hospital, Seoul, Korea 23 Division of Healthcare Technology Assessment Research, National Evidence-based Healthcare Collaborating Agency, Seoul, Korea 24 Department of Neurology, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea 25 Department of Neurology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, Korea

2025; 24 1 - 23
Dementia; Alzheimer Disease; Cholinesterase Inhibitors; Memantine; Practice Guidelines;
Original Article
2025; 24 24 - 43
Clinical Practice Guidelines for Dementia: Recommendations for the Pharmacological Treatment of Behavioral and Psychological Symptoms

Gihwan Byeon ,1 Dong Woo Kang ,1 Yeshin Kim ,2 Geon Ha Kim ,3 Ko Woon Kim ,4 Hee-jin Kim ,5 Seunghee Na ,6 Kee Hyung Park ,7 Young Ho Park ,8 Jeewon Suh ,9 Joon Hyun Shin ,10 YongSoo Shim ,11 YoungSoon Yang ,12 Yoo Hyun Um ,13 Seong-il Oh ,14 Sheng-Min Wang ,15 Bora Yoon ,16 Sun Min Lee ,17 Juyoun Lee ,18 Jin San Lee ,14 Hak Young Rhee ,19 Jae-Sung Lim ,20 Young Hee Jung ,21 Juhee Chin ,22 Hyemin Jang ,23 Yun Jeong Hong ,24 Miyoung Choi ,25 Jae-Won Jang ,2 The Korean Dementia Association’s Quality Management Committee
1 Department of Psychiatry, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea 2Department of Neurology, Kangwon National University Hospital, Chuncheon, Korea 3Department of Neurology, Ewha Womans University Mokdong Hospital, Seoul, Korea 4Department of Neurology, Jeonbuk National University Medical School and Hospital, Jeonju, Korea 5Department of Neurology, Hanyang University Hospital, Seoul, Korea 6Department of Neurology, The Catholic University of Korea, Incheon St. Mary’s Hospital, Incheon, Korea 7Department of Neurology, College of Medicine, Gachon University Gil Medical Center, Incheon, Korea 8Department of Neurology, Seoul National University Bundang Hospital, Seoul, Korea 9Department of Neurology, National Medical Center, Seoul, Korea 10Dr Shin’s Neurology Clinic, Wonju, Korea 11 Department of Neurology, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea 12Department of Neurology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea 13 Department of Psychiatry, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea 14 Department of Neurology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea 15Department of Psychiatry, The Catholic University of Korea, Yeouido St. Mary’s Hospital, Seoul, Korea 16 Department of Neurology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea 17Department of Neurology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea 18Department of Neurology, Chungnam National University Hospital, Daejeon, Korea 19 Department of Neurology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, Korea 20Department of Neurology, Asan Medical Center, Seoul, Korea 21 Department of Neurology, Hallym Sacred Heart Hospital, College of Medicine, Hallym University, Anyang, Korea 22Department of Psychology, Doheon Academy, Hallym University, Chuncheon, Korea 23Department of Neurology, Seoul National University Hospital, Seoul, Korea 24 Department of Neurology, The Catholic University of Korea, Uijeongbu St. Mary’s Hospital, Uijeongbu, Korea 25Division of Healthcare Research, National Evidence-based Healthcare Collaborating Agency, Seoul, Korea

Clinical Practice Guidelines for Dementia: Recommendations for the Pharmacological Treatment of Behavioral and Psychological Symptoms

Gihwan Byeon ,1 Dong Woo Kang ,1 Yeshin Kim ,2 Geon Ha Kim ,3 Ko Woon Kim ,4 Hee-jin Kim ,5 Seunghee Na ,6 Kee Hyung Park ,7 Young Ho Park ,8 Jeewon Suh ,9 Joon Hyun Shin ,10 YongSoo Shim ,11 YoungSoon Yang ,12 Yoo Hyun Um ,13 Seong-il Oh ,14 Sheng-Min Wang ,15 Bora Yoon ,16 Sun Min Lee ,17 Juyoun Lee ,18 Jin San Lee ,14 Hak Young Rhee ,19 Jae-Sung Lim ,20 Young Hee Jung ,21 Juhee Chin ,22 Hyemin Jang ,23 Yun Jeong Hong ,24 Miyoung Choi ,25 Jae-Won Jang ,2 The Korean Dementia Association’s Quality Management Committee
1 Department of Psychiatry, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea 2Department of Neurology, Kangwon National University Hospital, Chuncheon, Korea 3Department of Neurology, Ewha Womans University Mokdong Hospital, Seoul, Korea 4Department of Neurology, Jeonbuk National University Medical School and Hospital, Jeonju, Korea 5Department of Neurology, Hanyang University Hospital, Seoul, Korea 6Department of Neurology, The Catholic University of Korea, Incheon St. Mary’s Hospital, Incheon, Korea 7Department of Neurology, College of Medicine, Gachon University Gil Medical Center, Incheon, Korea 8Department of Neurology, Seoul National University Bundang Hospital, Seoul, Korea 9Department of Neurology, National Medical Center, Seoul, Korea 10Dr Shin’s Neurology Clinic, Wonju, Korea 11 Department of Neurology, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea 12Department of Neurology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea 13 Department of Psychiatry, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea 14 Department of Neurology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea 15Department of Psychiatry, The Catholic University of Korea, Yeouido St. Mary’s Hospital, Seoul, Korea 16 Department of Neurology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea 17Department of Neurology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea 18Department of Neurology, Chungnam National University Hospital, Daejeon, Korea 19 Department of Neurology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, Korea 20Department of Neurology, Asan Medical Center, Seoul, Korea 21 Department of Neurology, Hallym Sacred Heart Hospital, College of Medicine, Hallym University, Anyang, Korea 22Department of Psychology, Doheon Academy, Hallym University, Chuncheon, Korea 23Department of Neurology, Seoul National University Hospital, Seoul, Korea 24 Department of Neurology, The Catholic University of Korea, Uijeongbu St. Mary’s Hospital, Uijeongbu, Korea 25Division of Healthcare Research, National Evidence-based Healthcare Collaborating Agency, Seoul, Korea

2025; 24 24 - 43
Dementia; Behavioral Symptoms; Drug Therapy; Guideline;
Original Article
2025; 24 44 - 53
Tracking Cognitive Trajectories in Mild Cognitive Impairment Using a Machine Learning Technique of Subtype and Stage Inference

Hui Jin Ryu ,1 Kyoung Ja Kwon ,2 Yeonsil Moon 1,3
1Department of Neurology, Konkuk University Medical Center, Seoul, Korea 2 Center for Geriatric Neuroscience Research, Institute of Biomedical Science and Technology, Konkuk University School of Medicine, Seoul, Korea 3Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Korea

Tracking Cognitive Trajectories in Mild Cognitive Impairment Using a Machine Learning Technique of Subtype and Stage Inference

Hui Jin Ryu ,1 Kyoung Ja Kwon ,2 Yeonsil Moon 1,3
1Department of Neurology, Konkuk University Medical Center, Seoul, Korea 2 Center for Geriatric Neuroscience Research, Institute of Biomedical Science and Technology, Konkuk University School of Medicine, Seoul, Korea 3Research Institute of Medical Science, Konkuk University School of Medicine, Seoul, Korea

2025; 24 44 - 53
Neuropsychology; Neurocognitive disorders; Mild Cognitive Impairment; Mental Status and Dementia Tests; Cognition;
Original Article
2025; 24 54 - 68
Effects of Cognitive and Depressive Status on Empathy in Healthy Elderly, Amnestic MCI, and Dementia of the Alzheimer’s Type

Seonyeong Yang,1 Sun Hwa Lee,2 Jaeho Kim,2 Soo-Jin Cho,2 Yeonwook Kang1
1Department of Psychology, College of Social Sciences, Hallym University, Chuncheon, Korea 2Department of Neurology, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea

Effects of Cognitive and Depressive Status on Empathy in Healthy Elderly, Amnestic MCI, and Dementia of the Alzheimer’s Type

Seonyeong Yang,1 Sun Hwa Lee,2 Jaeho Kim,2 Soo-Jin Cho,2 Yeonwook Kang1
1Department of Psychology, College of Social Sciences, Hallym University, Chuncheon, Korea 2Department of Neurology, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea

2025; 24 54 - 68
Empathy; Depression; Mild Cognitive Impairment; Dementia of the Alzheimer’s Type;
Original Article
2025; 24 69 - 73
A Case of Combined Corticobasal Degeneration and Alzheimer’s Disease Pathology: Clinical Presentation, and Diagnosis

Seoyeon Baek ,1 Sun Young Chae ,2 Jae Seung Kim ,3 Hyung-Ji Kim 1
1 Department of Neurology, Uijeongbu Eulji Medical Center, Eulji University School of Medicine, Uijeongbu, Korea 2 Department of Nuclear Medicine, Uijeongbu Eulji Medical Center, Eulji University School of Medicine, Uijeongbu, Korea 3 Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

A Case of Combined Corticobasal Degeneration and Alzheimer’s Disease Pathology: Clinical Presentation, and Diagnosis

Seoyeon Baek ,1 Sun Young Chae ,2 Jae Seung Kim ,3 Hyung-Ji Kim 1
1 Department of Neurology, Uijeongbu Eulji Medical Center, Eulji University School of Medicine, Uijeongbu, Korea 2 Department of Nuclear Medicine, Uijeongbu Eulji Medical Center, Eulji University School of Medicine, Uijeongbu, Korea 3 Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

2025; 24 69 - 73
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